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Changes of somatostatin neurons in Alzheimer's disease rats model

Jing Dong

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Abstract

Objective:To observe the changes of somatostatin (SS) neurons in Alzheimer's (AD) disease rats model induced by D-galactose and ibotenic acid(IBO). Methods:Rats AD model were induced by D-galactose and lesion of basal Meynert nucleus with IBO. Numbers and average area of Hippocampal SS neurons were detected with immunohistochemistry ABC technique and immage analysis. Results:Compared with control rats, numbers of SS neurons in model group were significantly decreased (P0.01);grey value of model group was increased (P0.01), suggesting SS content decreased significantly. Average area of SS neurons between model rats and control rats had no significant difference. Conclusion:Hippocampal SS neurons decline obviously in AD model induced by D-galactose and lesion of basal Meynert nucleus with IBO.

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Objective:To observe the changes of somatostatin (SS) neurons in Alzheimer's (AD) disease rats model induced by D-galactose and ibotenic acid(IBO). Methods:Rats AD model were induced by D-galactose and lesion of basal Meynert nucleus with IBO. Numbers and average area of Hippocampal SS neurons were detected with immunohistochemistry ABC technique and immage analysis. Results:Compared with control rats, numbers of SS neurons in model group were significantly decreased (P0.01);grey value of model group was increased (P0.01), suggesting SS content decreased significantly. Average area of SS neurons between model rats and control rats had no significant difference. Conclusion:Hippocampal SS neurons decline obviously in AD model induced by D-galactose and lesion of basal Meynert nucleus with IBO.

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Available abstract

Objective:To observe the changes of somatostatin (SS) neurons in Alzheimer's (AD) disease rats model induced by D-galactose and ibotenic acid(IBO). Methods:Rats AD model were induced by D-galactose and lesion of basal Meynert nucleus with IBO. Numbers and average area of Hippocampal SS neurons were detected with immunohistochemistry ABC technique and immage analysis. Results:Compared with control rats, numbers of SS neurons in model group were significantly decreased (P0.01);grey value of model group was increased (P0.01), suggesting SS content decreased significantly. Average area of SS neurons between model rats and control rats had no significant difference. Conclusion:Hippocampal SS neurons decline obviously in AD model induced by D-galactose and lesion of basal Meynert nucleus with IBO.

Key concepts: Ibotenic acid, Somatostatin, Galactose, Internal medicine, Endocrinology, Lesion, Basal (medicine), Hippocampal formation

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