Study on genotypes of extended spectrum β-lactamases and antibiotic resistance of Proteus mirabilis strains

Objective:To understand the antibiotic resistance,distribution of nosocomial infections and genotypes of extended spectrum β-1actamases of Proteus mirabilis strains isolated from clinical specimens.Methods: A total of 105 strains of Proteus mirabilis were analysed for their antimicrobial susceptibility.The gene of ESBLs-producing isolates were detected by PCR and then sequenced.Results: None of these Proteus mirabilis isolates was found resistant to imipenem,mempenem and cefoxitin,while their drug resistance rates to ciprofloxacin,levofloxacin and the third-generation cephalosporins were at low level,17(16.2%) strains were identified as ESBls producers.The genotypes of these strains included CTX-M-14(14/17),CTX-M-15(3/17).Conclusion: The detection rate of ESBL-producing Proteus mirabilis was still low.17 strains of ESBL-producing Proteus mirabilis,with the genotype of CTX-M-15 and CTX-M-14,were resistant to many antibacterial agents.More attention should be paid to survey such strains.