Expression and Significance of E2F3 and AR in Prostate Cancer

Objective:To investigate expression levels of E2F3 and AR in prostate cancer(PCa) and discuss their relationship with the clinical stage and pathologic grade.Methods:The expressions of E2F3 and AR were detected by immunohistochemistry(IHC) in tissues from 50 cases of prostate cancer and 50 cases benign prostatic hyperplasia(BPH).The relationship between expressions of E2F3 and AR with the clinical stage and pathologic grade was analyzed by SPSS 13.0.Results:The positive rate of E2F3 was 20%(2/10) and 66%(33/50) for BPH and prostate cancer respectively.The expression level of E2F3 was higher in prostate cancer than that in BPH(P 0.05).There was a positive correlation in expression of E2F3 between the clinical stage and pathological grade(rs = 0.471 and 0.329,P 0.05 and P 0.01).The expression of AR was lower in PCa than that of BPH(P 0.05).The expression of AR in PCa was negatively correlated with the clinical stage and pathological grade(rs =-0.403 and-0.391,P 0.01).There was no correlation between the expression of E2F3 and the expression of AR in PCa(rs =-0.017,P 0.05).Conclusion:E2F3 may play an important role in the onset and progression of prostate cancer.