Difference cause analysis on thrombocytopenia by different bacterial infections in patients with sepsis

Objective To analyze primarily the difference causes of thrombocytopenia by different bacterial infections in patients with sepsis,to distinguish the biochemical characteristics of Gram-positive bacteria( G+) and Gram-negative bacteria( G-),and to provide the reference for the clinical early prevention of multiple organ failure and reduce the mortality rate. Methods A total of 155 sepsis patients,56 patients with non-sepsis( infection group) and43 non-infected controls were enrolled,and their platelet( PLT),procalcitonin( PCT),C reactive protein( CRP),white blood cell( WBC),the percentage of neutrophils( NE) and Bcl-x L protein levels were determined. The results were analyzed statistically. Blood culture was performed simultaneously,75 cases of blood culture-positive sepsis patients were classified into G+and G-groups. Their PLT,PCT,Bcl-x L protein and different PCT cross-section percentages were analyzed. Results Biochemical parameters of sepsis group had obvious difference with those of control group( P 0. 01). Compared with infection group,serum PLT,PCT,CRP and Bcl-x L protein levels were significantly different( P 0. 01),and WBC and the percentage of NE had no statistical significance( P 0. 05). In infection group,PCT,CRP,WBC,NE percentage had statistical significance compared with those in control group( P 0. 01),but the differences of PLT and Bcl-x L protein were not significant( P 0. 05). For G+and G-groups in sepsis patients,when PCT 2. 0 ng / m L,there was no statistical significance( P 0. 05). When 2. 0 ng / m L ≤ PCT ≤10. 0 ng / m L,the percentage in G+group was significantly higher than that in G-group( P 0. 01). When PCT ≥10. 0 ng / m L,the percentage in G-group was significantly higher than that in G+group( P 0. 01). PLT and PCT levels in G-group were lower than those in G+group( P 0. 01). Conclusions The reduction of PLT and the increase of PCT are related to the apoptosis of PLT caused by Bcl-x L protein. G-sepsis is easier to start PLT apoptosis than G+sepsis with higher risk.