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[Study on the inhibitory effect of Reduqing Oral Liquid on respiratory syncytial virus in vitro].

Shenghai Huang, Xiao-Liang Feng, Wei Yong Liu

Abstract

OBJECTIVE: To explore the antiviral effect of Reduqing Oral Liquid on respiratory syncytial virus (RSV). METHODS: The anti-RSV effect of Reduqing Oral Liquid in Hep-2 cell culture was investigated by the cytopathic effect (CPE) inhibition assay and MTT assay, with ribavirin as the positive control drug. RESULTS: Reduqing Oral Liquid was effectively antiviral agent for RSV in a concentration-dependent manner in vitro. The median toxic concentration (TC50) was 9182.4 mg/L, the median effective concentration (EC50) was 559.8 mg/L and the treatment index (TI) was 16.4. CONCLUSION: Reduqing Oral Liquid has obvious inhibitory effect on RSV in vitro.

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Key concepts: Ribavirin, Cytopathic effect, In vitro, EC50, Virus, MTT assay, Respiratory system, Chemistry