The effect of atorvastatin on urine protein and correlation factor in older patients with early diabetic nephropathy without hyperlipemia

Objective To study the effect of atorvastatin on urine protein(UAER),endothelin(ET),nitrogen monoxidum(NO),C-Reactive protein(CRP)in older patients with early diabetic nephropathy(DN)without hyperlipemia.Methods Fifty older DN without hyperlipemia were randomly divided into two groups,the conventional treatment group(n=25),conventional treatment plus atorvastatin group(unitive group,n=25),and 25 normal controls were chosen as normal control.The plasma serum lipids(CH,TG,LDL,HDL),ET,NO,CRP and urinary albumin excretion rate(UAER)were examined before and after the treatment.Results The levels of ET,CRP in patients with DN was higher than those in normal control group,and the level of NO was lower.After 12 weeks of treatment,the levels of serum lipids,ET,NO and UAER had no changes in the conventional treatment group,but they were improved in unitive group.Conclusion Atorvastatin can decrease the levels of UAER in older patients with early diabetic nephropathy,which may be due to its correction of abnomal renal hemodynamics through decreasing ET and increasing NO,improving serum lipids,lessening inflammatory reaction.