THE SIGNIFICANCE OF THE CHANGE OF PCNA AND PTEN PROTEIN EXPRESSION IN CARCINOGENESIS OF INVERTED PAPILLOMA OF NASAL CAVITIES AND PARANASAL SINUSES

Objective To investigate the expression of proliferating cell nuclear Antigen(PCNA) and assisted with the tension of protein and protein homology,the No.10 chromosome lost phosphatase gene(phosphatase and tensin homology deleted on chromosome ten,PTEN)in inverted papilloma of nasal cavities and paranasal sinuses and its carcinogenesis.Methods PCNA and PTEN protein expression in 55 paraffin tissue specimen of nasal cavities and paranasal sinuses,including inverted papilloma,atypical hyperplasia and papillary carcinoma were detected using immunohistochemical EnVision two step method.Results PCNA and PTEN protein were expressed in inverted papilloma,atypical hyperplasia and papillary carcinoma.The expression of PTEN protein showed a different distribution pattern to that of PCNA,the PCNA protein expression have a rising gradually and PTEN protein expression is decreasing gradually.Conclusions PCNA and PTEN protein expression change are closely related to the malignant transformation of inverted papilloma.PCNA expression up-regulated and loss of PTEN expressions may be a favorable marker and prompted prognosis in patient with inverted papilloma of nasal cavities and paranasal sinuses.