A study on alteration of endothelium-dependent vasodilation in type 2 diabetes mellitus without angiopathy

Objective To study the alteration of endothel ium-dependent vasodilation in the early stage of type 2 diabetes mellitus.Methods Fifty type 2 diabetic patients and 25 healthy individua ls were selected randomly,and high resolution ultrasound was performed to measur e changes in brachial artery diameter at rest,after reactive hyperemia(with incr eased flow producing an endothelium-dependent dilation) and after sublingual gl yceryltrinitrate(GNT,an endothelium-independent diator).Results The flow-mediated arterial dilation in type 2 diabetes group was 3.62%,which was significantly lower than that in control(4.68%)( P 0.05).The baseline vessel size,baseline flow and GNT induced arterial dilatio n in both groups were not significantly different( P 0.05).Conclusion The endothelium-dependent arterial dilation is decr eased in the early stage of type 2 diabetic patients.