Analysis on drug resistance of Helicobacter pylori clinical isolates in Shijiazhuang area

Objective To know about the antibiotic resistance of Helicobacter pylori(H.pylori)clinical isolates in Shijiazhuang area and to provide the clinical guidelines for choosing effective agents for H.pylori eradication therapy.Methods Gastric mucosa tissues of 200patients with H.pylori infections were collected to isolate and identify H.pylori.Kirby-Bauer test was performed to test the susceptibility of H.pylori clinical isolates to metronidazole,clarithromycin,amoxicillin,levofloxacin,furanzolidone and tetracycline.Results A total of 121H.pylori strains were isolated from 200samples(60.5%)and there were no statistical significance in the isolation rate between the patients with different gender and age(P 0.05).The resistance rate of H.pylori to metronidazole,clarithromycin,amoxicillin,levofloxacin,furanzolidone and tetracycline was respectively 95.0%(115/121),26.4%(32/121),2.5%(3/121),5.8%(7/121),0and 3.3%(4/121).There were no statistical significance between different gender and age(P 0.05).Conclusion In Shijiazhuang area,the resistance rate of H.pylori to metronidazole and clarithromycin is higher,the medicines should not be used as first-line agents for H.pylori treatment.The resistance rate of H.pylori to amoxicillin,levofloxacin,furanzolidone and tetracycline is lower,and these medicines can be used as major agents for H.pylori treatment.