An experimental study of the Roux-en-Y reconstruction on intestinal evacuation in rats undergoing subtotal gastrectomy

Objective To investigate the effect of Roux en Y gastrointestinal reconstruction on the function of small bowel evacuation in rats undergoing subtotal gastrectomy. [WT5”HZ]Methods[WT5”BZ] Using radiolabeled test meal we studied the postoperative gastrointestinal evacuation in rats receiving GI reconstructions of Billroth Ⅰ,Roux en Y and Roux en Y plus truncal vagotomy(TV) respectively after subtotal gastrectomy.[WT5”HZ]Results[WT5”BZ] The bimodal distributions of radioactivity in GI tract were found in the sham,Billroth I, and Roux en Y group. The second radioactive peak was in the middle portion of the intestine in sham group,in the middle and distal portion in Billroth I group and in the proximal and middle portion in Roux en Y group. The unimodal radioactive peak was shown in the gastric remanant and the proximal small bowel in Roux en Y plus TV group. Compared with Billroth Ⅰ group the stasis of radioactive test meal in the first intestinal segment in groups with Roux en Y reconstruction was more obvious(Billroth I vs Roux en Y P 0 05, Billroth I vs Roux en Y plus TV P 0 01). [WT5”HZ]Conclusion[WT5”BZ] The findings strongly suggested that vagotomy was not responsible for the stasis problem in proximal small intestine often seen clinically in Roux en Y GI reconstruction.