Activation of Th2 cells in patients with rheumatoid arthritis

Objective To study and discuss the effect of Th2 cells on pathogenesis of rheumatoid arthritis(RA).Methods Some CDs in peripheral blood lymphocytes were detected by flow cytometry and IL 4 and IL 6 levels in plasma by enzyme linked immunoassay.Results Compared with normal control, CD25 + cells ( t = 3.115, P 0.01) and CD19 + cells ( t =2.561, P 0.05) were all elevated in RA patients, which shoeed respectively very significant and significant difference. While the level of CD8 +/CD28 - cells was greatly reduced ( P 0.01). The levels of IL 4 ( t =2.421, P 0.05) and IL 6 ( t =3.156, P 0.01) were higher than those of the control ( t =2.901, P 0.01 ). As to the amount of CD3 + and CD4 + cells, there was no overt difference between the RA patients and the control ( P 0.05).Conclusion The excessive activation of Th2 cell in RA patients is a major performance of their cellular immunoregulation disorder.