Clinical significance of detection of high sensitive C-reactive protein,blood lipids and uric acid in patients with coronary heart disease

Objective:To investigate clinical significance of detection of high sensitive C-reactive protein(hsCRP),blood lipids and uric acid(UA) in patients with coronary heart disease(CHD).Methods:A total of 159 CHD patients(CHD group) were selected,including 65 cases with stable angina pectoris,48 cases with unstable angina pectoris and 46 cases with acute myocardial infarction.Another 75 healthy subjects were regard as healthy control group.Serum levels of hsCRP,blood lipids and UA were measured and compared among all groups.Results:Compared with healthy control group,there were significant increase in levels of hsCRP [(1.4±0.3) mg/L vs.(8.5±0.4) mg/L],triglyceride [(1.8±0.5) mmol/L vs.(2.4±0.6) mmol/L],total cholesterol [(4.8±0.3) mmol/L vs.(6.2±0.4) mmol/L],low density lipoprotein cholesterol [(2.5±0.7) mmol/L vs.(6.0±0.2) mmol/L],apolipoprotein(Apo) B [(0.8±0.2) mmol/L vs.(2.8±0.9) mmol/L] and UA [(278.5±51.4) μmol/L vs.(418.6±62.1) μmol/L],P0.05 or 0.01;and significant decrease in levels of high density lipoprotein cholesterol [(2.6±0.3) mmol/L vs.(1.4±0.4) mmol/L] and Apo A1 [(2.8±0.4) mmol/L vs.(2.2±0.5) mmol/L] in CHD group,P0.01 both.There were significant difference(P0.05 or 0.01)on above indexes among all subgroups of CHD and healthy control group.Conclusion:Detection of high sensitive C-reactive protein,blood lipids and uric acid is of important significance for early diagnosis and prognosis judgment of coronary heart disease.