Research Progress of MicroRNA Involved in Epigenetic Regulation Mechanisms in Leukemia

Epigenetic abnormality is closely related to the development of malignant tumors.MicroRNAs(miRNAs)are a series of short non-coding RNAs that can regulate the expressions of protein-coding genes posttranscriptionally,of which regulatory mechanism belongs to the broad epigenetics.In recent years,the research on miRNA has shown that the interactions between miRNA and epigenetic have a close relationship with the modulation about blood cell differentiation and occurrence,development,diagnosis and treatment of hematologic malignancies,which may offer a new access to the diagnosis and treatment for neoplasms.