Evaluation on the practibility of peak intensity of liver parenchyma during perfusion in patients with of cirrhosis by contrast-enhanced ultrasonography

Objective To evaluate the practibility of perfusion assessed by contrast-enhanced ultrasonography( CEUS) for accurately and non-invassively predicting cirrhosis. Methods Thirty-five patients with cirrhosis and twenty-one healthy controls were given with CEUS examination,and time-intensity curves( TIC) were drawn as the regions of interest localities in liver parenchyma by using QLAB analyzing soft ware. The parameters of these two groups were as follows: peak intensity of liver parenchyma( Ipeak) by independent-samples t test,and the diagnostic value of parameters were analyzed by receiver operating characteristic( ROC) curve. Results Ipeak was smaller in cirrhosis patients than that of controls,the difference was statistically significant. The critical value of Ipeak was 30. 20 and when it used for diagnosis of cirrhosis,its sensitivity reached 90. 4% and its specificity was 74. 8%. Conclusion CEUS can reflect the changes in blood perfusion of liver in cirrhotic patients. The parameter Ipeak of CEUS is significantly different between these two groups and it can be used as non-invasive parameter for diagnosis of cirrhosis.