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2009•Xiandai shengwu yixue jinzhanRequires access

Expression of Inducible Nitric Oxide Synthase and Endothelin after Spinal Cord Injury in Rats

Fan Dong-sheng

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Abstract

Objective:To study the expression of inducible nitric oxide synthase(INOS) and endothelin(ET) after spinal cord inju-ry in rats.Methods:36 adult Wistar rats were randomly divided into normal,mild(moderate) and severe injury groups.The rats were killed at 14 days after spinal cord injury.Expression of INOS and ET was determined with S-P immunohistochemical methods.Results:There were no INOS and ET expression in cells of normal group.14 days after spinal cord injury,the INOS(ET) levels in mild(moderate) and severe groups were 14.8%(11.1%) and 59.3%(51.9%),respectively;there were significant difference(P=0.004;P=0.013).Conclu-sions:INOS and ET take part in the process of rats' spinal cord injury.The expression of INOS and ET showed increased tendency with the spinal cord injury degree.

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Objective:To study the expression of inducible nitric oxide synthase(INOS) and endothelin(ET) after spinal cord inju-ry in rats.Methods:36 adult Wistar rats were randomly divided into normal,mild(moderate) and severe injury groups.The rats were killed at 14 days after spinal cord injury.Expression of INOS and ET was determined with S-P immunohistochemical methods.Results:There were no INOS and ET expression in cells of normal group.14 days after spinal cord injury,the INOS(ET) levels in mild(moderate) and severe groups were 14.8%(11.1%) and 59.3%(51.9%),respectively;there were significant difference(P=0.004;P=0.013).Conclu-sions:INOS and ET take part in the process of rats' spinal cord injury.The expression of INOS and ET showed increased tendency with the spinal cord injury degree.

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Available abstract

Objective:To study the expression of inducible nitric oxide synthase(INOS) and endothelin(ET) after spinal cord inju-ry in rats.Methods:36 adult Wistar rats were randomly divided into normal,mild(moderate) and severe injury groups.The rats were killed at 14 days after spinal cord injury.Expression of INOS and ET was determined with S-P immunohistochemical methods.Results:There were no INOS and ET expression in cells of normal group.14 days after spinal cord injury,the INOS(ET) levels in mild(moderate) and severe groups were 14.8%(11.1%) and 59.3%(51.9%),respectively;there were significant difference(P=0.004;P=0.013).Conclu-sions:INOS and ET take part in the process of rats' spinal cord injury.The expression of INOS and ET showed increased tendency with the spinal cord injury degree.

Key concepts: Nitric oxide synthase, Spinal cord, Spinal cord injury, Nitric oxide, Immunohistochemistry, Medicine, Endothelin 1, Anesthesia

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