Analysis of the diagnostic significance of HLA-B27 in spondyloarthropathy and non-spondyloarthropathy:report of 4817 cases

Objective:To study the application of HLA-B27 antigen detection in diagnosis of spondyloarthropathy(SpAs) in patients with low back pain.Methods:HLA-B27 antigen detection with complement-dependent lymphocytotoxicity was performed in 4 414 patients who sought medical consultation with low back pain and 403 healthy controls.Analysis of HLA-B27 positive distributions in different gender and diseases(SpA and have non-SpA)was performed.Results:The positive rate of HLA-B27 antigen was 49.81% in 4 414 patients with low back pain,while no significant difference revealed between genders(P0.05).Positive rates of HLA-B27 in patients with ankylosing spondylitis(AS),undifferentiated spondyloarthropathy(USpA),Juvenile spondyloarthropathy(JSpAs),reactive arthritis(ReA),psoriatic arthritis(PsA) and non-SpAs were 90.07%,28.85%,68.81%,52.94%,67.74% and 19.33%,respectively,with significant differences with the healthy control group(P0.05).Conclusions:Positive HLA-B27 detection can be found in patients with non-SpAs,suggesting that HLA-B27 is not an independent diagnostic factor of SpA.