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2012•Journal of Preventive Medicine InformationRequires access

Gas Chromatographic Method for the Determination of Methanol in Biological Samples

Chen Hong-en

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Abstract

Objective To establish gas chromatographic method for determination of methanol in biological samples.Methods The biological samples including blood,urine and content of stomach were placed in head-space vial,and added sodium chloride and water for gas-liquid equilibrium under 60℃ water-bath for 20 minutes,external standard quantification was used for definite quantitative determination.Results For spiked level of 0.10-1.00mg,the recovery rate of the method was in the range of 94.7%-102%,with the relative standard deviations of 3.5%-6.3%.Conclusion This method is simple,reliable,accurate and suitable for the determination of methanol in biological samples.

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What this paper is about

Objective To establish gas chromatographic method for determination of methanol in biological samples.Methods The biological samples including blood,urine and content of stomach were placed in head-space vial,and added sodium chloride and water for gas-liquid equilibrium under 60℃ water-bath for 20 minutes,external standard quantification was used for definite quantitative determination.Results For spiked level of 0.10-1.00mg,the recovery rate of the method was in the range of 94.7%-102%,with the relative standard deviations of 3.5%-6.3%.Conclusion This method is simple,reliable,accurate and suitable for the determination of methanol in biological samples.

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Available abstract

Objective To establish gas chromatographic method for determination of methanol in biological samples.Methods The biological samples including blood,urine and content of stomach were placed in head-space vial,and added sodium chloride and water for gas-liquid equilibrium under 60℃ water-bath for 20 minutes,external standard quantification was used for definite quantitative determination.Results For spiked level of 0.10-1.00mg,the recovery rate of the method was in the range of 94.7%-102%,with the relative standard deviations of 3.5%-6.3%.Conclusion This method is simple,reliable,accurate and suitable for the determination of methanol in biological samples.

Key concepts: Chromatography, Methanol, Chemistry, Relative standard deviation, Biological fluids, Gas chromatography, Detection limit, Organic chemistry

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