The Changes of Serum Matrix Metalloproteinase-9 and Tissue Inhibitor Metalloproteinase-1 in Essential Hypertension

Objective To investigate the significance of serum Metrix Metalloproteinase_9(MMP_9) and tissue inhibitor Metalloproteinase_1(TIMP_1), and their relationship with left ventricular hypertrophy in essential hypertension. Methods Using ELISA, serum levels of MMP_9 and TIMP_1 were measured in 40 patients with essential hypertension and 28 healthy people. Doppler echocardiography was performed in all study subjects, left ventricular mass index was defined as index for left ventricular hypertrophy. Results 1. Serum concentration of MMP_9 was lower and serum level of TIMP_1 was higher in hypertensive patients than those in normotensive control subjects( 296.38±159.23ng.ml-1 vs 499.62±334.80ng.ml-1,355.99±114.95ng.ml-1 vs 205.45±38.77ng.ml-1;P0.001 and P0.05,respectively). 2.Serum MMP_9 level had no different between patients with left ventricular hypertrophy and without left ventricular hypertrophy, but serum TIMP_1 level was higher in patients with left ventricular hypertrophy (491.27±75.03ng.ml-1 vs 198.47±42.98ng.ml-1,P0.001).Conclusions Systemic extracelluar degradation of collagen is depressed in hypertensive patients because of abnormal metabolism of MMP-9 and TIMP-1, the increase in concentration of serum TIMP-1 can reflect left ventricular hypertrophy of essential hypertension.