Relation between the decline rate of glomerular filtration rate and clinical characteristics in diabetic nephropathy

Objective To observe relation between decline rate of GFR and clinical characteristics in diabetic nephropathy.Methods 309 type 2 diabetic patients in 1994-2008 were divided into three groups according to urinary albumin excretion rate(UAER):normal UAER,micro-UAER and large UAER group. Serum creatinine concentrations (Scr) and GFR were measured to observe GFR difference between nonprogress group and progress group after average 3.5-years.The decline rate of GFR was calculated. Results There was difference in GFR between last and baseline calculation in spite of nonprogress or progress of three groups (P 0.01).The average annual decline of GFR was 1.5 ± 7.3 ml/min in nonprogress group of normal albuminuria,3.2±3.9 ml/min in the progress group of normal albuminuria, 2.7±9.2m1/min in the nonprogress group of microalbuminuria,4.1±8.5m1/min in the progress group of microalbuminuria,whereas 9.4±11.9 ml/min in the macroalbuminuric group.There were significant differences between normal albuminuric,microalbuminuric and macroalburninuric groups in the decline rate of GFR in spite of nonprogress or progress(P0.01).HbA1 c and SBP were positively correlated with the decline rate of GFR (r= 0.92,0.06,P0.05).Conclusions With albuminuria becoming more serious,the rate of GFR decline is severer.HbA_1 c and SBP are important dangerous factors for the decline rate of GFR.