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Expression of aquaporin 8 in human placenta and fetal membranes

Hongbo Qi

Open publisher page 3 citations

Abstract

Objective:To detect Aquaporin 8(AQP8) expression in normal human fetal.membranes and placenta.Methods:Fetal membranes and placenta were collected from 6 women with intact membranes who underwent elective cesarean sections at term.RT-PCR was used to detect expression of AQP8mRNA,immunohistochemistry was used to detect expression of AQP8 protein.Results:AQP8 mRNA was detected in amniotic,chorion and placenta.Immunohistochemical results:showed AQP8 protein was mainly localized in the cytomembrane and cytoplasm of epithelial cell of amnion,trophocyte of chorion and syncytiotrophoblast of placenta.Conclusions:AQP8 may play an important role in amniontic fluid balance as well as maternal-fetal fluid balance.

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What this paper is about

Objective:To detect Aquaporin 8(AQP8) expression in normal human fetal.membranes and placenta.Methods:Fetal membranes and placenta were collected from 6 women with intact membranes who underwent elective cesarean sections at term.RT-PCR was used to detect expression of AQP8mRNA,immunohistochemistry was used to detect expression of AQP8 protein.Results:AQP8 mRNA was detected in amniotic,chorion and placenta.Immunohistochemical results:showed AQP8 protein was mainly localized in the cytomembrane and cytoplasm of epithelial cell of amnion,trophocyte of chorion and syncytiotrophoblast of placenta.Conclusions:AQP8 may play an important role in amniontic fluid balance as well as maternal-fetal fluid balance.

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Available abstract

Objective:To detect Aquaporin 8(AQP8) expression in normal human fetal.membranes and placenta.Methods:Fetal membranes and placenta were collected from 6 women with intact membranes who underwent elective cesarean sections at term.RT-PCR was used to detect expression of AQP8mRNA,immunohistochemistry was used to detect expression of AQP8 protein.Results:AQP8 mRNA was detected in amniotic,chorion and placenta.Immunohistochemical results:showed AQP8 protein was mainly localized in the cytomembrane and cytoplasm of epithelial cell of amnion,trophocyte of chorion and syncytiotrophoblast of placenta.Conclusions:AQP8 may play an important role in amniontic fluid balance as well as maternal-fetal fluid balance.

Key concepts: Syncytiotrophoblast, Placenta, Amnion, Aquaporin, Fetus, Fetal membrane, Amniotic fluid, Immunohistochemistry

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