Study on the Correlation of Idiopathic Thrombocytopenic Purpura and Human Herpevirus 6 Infection

Objective To study the correlation of Idiopathic Thrombocytopenic Purpura (ITP) and Human Her-pesvirus 6 (HHV-6) infection. Methods The HHV-6-DNA in bone marrow and peripheral blood of FTP patients was detected by PCR, and the healthy group and iron-deficiency anemia group were controls. Results In the peripheral blood, HHV-6-DNA positive rates of ITP group, iron-deficiency anemia group and heathy group were 25%(5/20), 10% (l/10)and 3.33% (1/30) respectively .The positive rate of ITP group was significantly higher than that of heathy group(P 0.05) .There was no significant difference between ITP group and iron-deficiency anemia group.HHV-6-DNA positive rates of bone marrow in 15 cases of ITP and 10 cases of iron-deficiency anemia were 46.67% (7/15) and 0, respectively, and there was no significant difference (P 0.05) between ITP group and iron-deficiency anemia group. HHV-6-DNA positive individuals in 10 cases of ITP before cure,at day 5 and at day 10 were 3,3 and 2 respectively. Conclusions There was correlation between ITP and HHV-6 infection. HHV-6-DNA positive rate in bone marrow was higher than that in peripheral blood.