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2006•Zhongguo weishengtaixue zazhiRequires access

The study of resistance mechanism in imipenem-resistance Pseudomonas aeruginosa

Rui Chen

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Abstract

Objective To study the mechanism of carbepenems resistance in Pseudomonas aeruginosa.Methods Using SDS-PAGE of outer membranes,scanning densimeter and three-dimentional test to study the relative amounts of OprD2 and β-Lactamases both in imipenem-resistant isolates and imipenem-susceptible isolates.Results The amounts of OprD2 in resistant isolates were significantly lower than those of susceptible isolates,and the activities of AmpC enzymes were higher than those of susceptible isolates.Conclusion Both the reduction of OprD2 and the increase of AmpC enzymes were primary elements in imipenem-resistance Pseudomonas aeruginosa in our hospital.

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Objective To study the mechanism of carbepenems resistance in Pseudomonas aeruginosa.Methods Using SDS-PAGE of outer membranes,scanning densimeter and three-dimentional test to study the relative amounts of OprD2 and β-Lactamases both in imipenem-resistant isolates and imipenem-susceptible isolates.Results The amounts of OprD2 in resistant isolates were significantly lower than those of susceptible isolates,and the activities of AmpC enzymes were higher than those of susceptible isolates.Conclusion Both the reduction of OprD2 and the increase of AmpC enzymes were primary elements in imipenem-resistance Pseudomonas aeruginosa in our hospital.

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Available abstract

Objective To study the mechanism of carbepenems resistance in Pseudomonas aeruginosa.Methods Using SDS-PAGE of outer membranes,scanning densimeter and three-dimentional test to study the relative amounts of OprD2 and β-Lactamases both in imipenem-resistant isolates and imipenem-susceptible isolates.Results The amounts of OprD2 in resistant isolates were significantly lower than those of susceptible isolates,and the activities of AmpC enzymes were higher than those of susceptible isolates.Conclusion Both the reduction of OprD2 and the increase of AmpC enzymes were primary elements in imipenem-resistance Pseudomonas aeruginosa in our hospital.

Key concepts: Imipenem, Pseudomonas aeruginosa, Microbiology, Pseudomonas, Biology, Drug resistance, Enzyme, Bacteria

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