2012•Biaoji mianyi fenxi yu linchuangRequires access
Detection of AFP-L3 in Diagnosis of Hepatocellular Carcinoma
Zhou Xiuyan
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Abstract
Objective To explore of clinical value of AFP-L3 in the diagnosis of patients with HCC.Methods The serum AFP-L3 levels in 137 patients with elevated AFP level were detected by ELISA.The patients were divided into HCC group and benign liver disease group.Results The serum levels of AFP-L3 in patients with HCC(109.04±62.51ng/mL) were significantly higher than those patients with benign liver diseases(25.96±49.43ng/mL,P0.001).The area under the ROC curve of AFP-L3 level in patients with HCC was 0.819.Taking AFP-L3 level ≥37.9ng/mL as diagnostic criteria,the sensitivity of AFP-L3 level in HCC diagnosis was 83.7%,and the specificity was 88.9%,with a total conformity rate of 85.4% compared to the confirmed clinical diagnosis.Conclusion The serum AFP-L3 levels might be a valuable biomarker in diagnosis and prediction of prognosis of HCC.The detection of AFP-L3 level by using ELISA is simple and cost-effective method.