2004•Chongqing Yike Daxue xuebaoRequires access
A study on the pathological efficacy of lamivudine in the treatment of chronic hepatitis B
Yang Chun
Open publisher page 0 citations
Abstract
Objective:To investigate hepatic pathohistological changes(including pathology,HBV markers in liver tissue) in patients with chronic hepatitis B treated with lamivudine.Methods:35 patients of chronic hepatitis B were randomly selected and administered with 100mg lamivudine orally daily for 1 year.The needle biopsy of liver were performed before and after treatment.The routine HE stained liver tissue sections were evaluated and Knodell pathological score were done.HBsAg,HBcAg,α-SMA in liver tissue were examined by immunohistochemisty method.Results:After 1 year histological assessment revealed that activity index of hepatic histology in 41.18% patients had a significant decrease,while necrosis in portal area,portal vein phlebitis and fibrosis were oboviously alleviated.The liver immunohistochemistry examination showed that HBcAg and α-SMA in liver decreased significantly in the patients with HBeAg seroconversion,but HBsAg had no obvious alteration.Conclusion:These results suggest that lamivudine(100mg/d) alleviate the inflammation degree,slow down the development of liver fibrosis after 1 year therapy.Once HBeAg seroconversion appears,HBcAg and α-SMA in liver decreased.