Related Research about Detecting Pepsinogen Subtypes in Atrophic Gastritis

Objective To study variation of serum pepsinogen(PG)subgroups content in healthy persons and patients with stomach diseases,and investgate serum PG subgroups significance for diagnosis of atrophic gastritis.Methods The changes of PGⅠ,PGⅡ and the PGⅠ/PGⅡ were measured with radioimmunoassay(RIA)in healthy persons,gastric ulcer,atrophic gastritis and gastric cancer patients.Data of the normal control group were statistically compared with every disease group.Results ① Compared with the normal control group,serum PGⅠ,PGⅠ/PGⅡ ratio of atrophic gastritis and gastric cancer patients was decreasing(q=5.97,q=6.18,P both0.05;q=6.24,q=6.34,P both0.01),serum PGⅠof gastric ulcer patients increasing(q=5.01,P0.05),PGⅠ/PGⅡdecreasing(q=4.72,P0.05).② Compared with the gastric ulcer group,serum PGⅠ of atrophic gastritis and gastric cancer were significantly lower than gastric ulcer(q=7.20,q=7.03,P both0.001),PGⅠ/PGⅡ ratio were also lower(q=7.20,P=0.001).③ PGⅠ and PGⅠ/PGⅡ of atrophic gastritis and gastric cancer group were not significantly different(q=1.05,q=1.36,P both0.05).When serum PGⅠ≤ 80μg/L and the PGⅠ/PGⅡ≤6,the sensitivity and specificity for detection of atrophic gastritis was 53.3% and 94.3% respectively.Conclusion The serum PGⅠ and PGⅠ/PGⅡ decrease is a risk factor for gastric cancer and atrophic gastritis.It may be a screening and supplementary diagnosis of serum marker.Serum PGⅠ≤ 80μg/L and the PGⅠ/PGⅡ≤ 6 has better specificity and sensitivity for atrophic gastritis.