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2011•Journal of Clinical HematologyRequires access

The role of detecting t(11;14),CD5 and CD23 in diagnosis of chronic lymphocytic leukemia

Hai‐Rong Qiu

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Abstract

Objective:To investigate the role of detecting t(11;14),CD5 and CD23 in diagnosis of chronic lymphocytic leukemia(CLL).Method:Flow cytometry(FCM) and conventional cytogenetics (CC) were performed in 45 patients who were firstly diagnosed as CLL,then interval fluorescence in situ hybridization(I-FISH) was performed in all patients.Result:All patients were negative with t(11;14) in CC.FCM results showed that 5 patients were CD5+CD23-and 40 patients were CD5+CD23+.Four patients with CD5+CD23-were positive with t(11;14) by I-FISH,but no patients with CD5+CD23+ were positive with t(11;14) by I-FISH.Conclusion:Examination of t(11;14),CD5 and CD23 plays an important role in diagnosing CLL.CLL shows features of t(11;14) negative and CD5+ CD23+.A few of mantle cell lymphoma(MCL) cases are misdiagnosed as CLL. MCL is identified as t(11;14) and CD5+ CD23-.

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Objective:To investigate the role of detecting t(11;14),CD5 and CD23 in diagnosis of chronic lymphocytic leukemia(CLL).Method:Flow cytometry(FCM) and conventional cytogenetics (CC) were performed in 45 patients who were firstly diagnosed as CLL,then interval fluorescence in situ hybridization(I-FISH) was performed in all patients.Result:All patients were negative with t(11;14) in CC.FCM results showed that 5 patients were CD5+CD23-and 40 patients were CD5+CD23+.Four patients with CD5+CD23-were positive with t(11;14) by I-FISH,but no patients with CD5+CD23+ were positive with t(11;14) by I-FISH.Conclusion:Examination of t(11;14),CD5 and CD23 plays an important role in diagnosing CLL.CLL shows features of t(11;14) negative and CD5+ CD23+.A few of mantle cell lymphoma(MCL) cases are misdiagnosed as CLL. MCL is identified as t(11;14) and CD5+ CD23-.

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Available abstract

Objective:To investigate the role of detecting t(11;14),CD5 and CD23 in diagnosis of chronic lymphocytic leukemia(CLL).Method:Flow cytometry(FCM) and conventional cytogenetics (CC) were performed in 45 patients who were firstly diagnosed as CLL,then interval fluorescence in situ hybridization(I-FISH) was performed in all patients.Result:All patients were negative with t(11;14) in CC.FCM results showed that 5 patients were CD5+CD23-and 40 patients were CD5+CD23+.Four patients with CD5+CD23-were positive with t(11;14) by I-FISH,but no patients with CD5+CD23+ were positive with t(11;14) by I-FISH.Conclusion:Examination of t(11;14),CD5 and CD23 plays an important role in diagnosing CLL.CLL shows features of t(11;14) negative and CD5+ CD23+.A few of mantle cell lymphoma(MCL) cases are misdiagnosed as CLL. MCL is identified as t(11;14) and CD5+ CD23-.

Key concepts: CD5, CD23, Chronic lymphocytic leukemia, Mantle cell lymphoma, Medicine, Lymphoma, Leukemia, Pathology

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