Expression of CDK2 inNon-small Cell Lung Cancer

To investigate the relationship between CDK2expression and metastasis in non-small cell lung cancer,50 non-small cell lung cancer tissues were divided into metastasis group and non-metastasis group.The expression of CDK2 in lung cancer tissues was detected by immunohistochemistry and Western-blot.The results showed specific CDK2protein staining was found in the nucleus of lung cancer cells.The expression level of CDK2protein was significantly higher in lung cancer tissues than those in tumor-adjacent tissues(P0.05).In addition,high levels of CDK2protein were positively correlated with the status of lymph node metastasis(P0.05),but had no correlation with histological type(P0.05). The conclusions was that over-expression of CDK2 may have correlation with the development of lung cancer and metastasis.