Expression of c-met and CXCR4 in colorectal cancer and the relationship with liver metastasis

Objective To explore the expression of c-met and CXCR4 in surrounding normal colorectal tissue,colorectal adenoma,colorectal cancer,and the relationship with development and liver metastasis of colorectal cancer.Methods Expression of c-met and CXCR4 was detected by EliVisionTM plus immunohisto chemical method in 15 normal colorectal mucosa,15 colorectal adenoma,48 colorectal cancer.The correlation of c-met and CXCR4 and their relationship of clinicopathologic characteristics including liver metastasis,lymphatic metastasis,Dukes staging,age,sex,location and differentiation was demonstrated.Results Expression of c-met and CXCR4 in normal colorectal tissue and colorectal adenoma was significantly lower than that in colorectal cancer.There was no difference between normal colorectal tissue and colorectal adenoma.Expression of c-met and CXCR4 in colorectal cancer with liver metastasis was significantly higher than that with no liver metastasis,and was relevant with lymphatic metastasis and Dukes staging but irrelevant with age,sex,location and differentiation.The expression of c-met in colorectal cancer was correlative with that of CXCR4.Conclusions The expression of c-met and CXCR4 in colorectal cancer is correlative and associated with carcinogenesis,development and liver metastasis in colorectal cancer.