Therapeutic effect of mechanical ventilation with prone positioning on acute respiratory distress syndrome

Objective To evaluate the therapeutic effect of mechanical ventilation with prone positioning on acute respiratory distress syndrome(ARDS).Method 42 patients with ARDS was underwent mechanical ventilated on prone position at early stage.The indexes included arterial blood gas,respiratory rate(RR),FiO2,PaO2/FiO2,chest lung compliance(C),and airway resistance(Raw) were evaluated before prone position and after 1 h,2 h,3 h,4 h and 8 h,following back to supine.Results Once the patients were turned to prone position mechanical ventilation,the FiO2 and PaO2/FiO2 were improved markedly,the peak values were occurred in 1 h and then decreased,after 8 h,both FiO2 and PaO2/FiO2 were still higher than pre therapy(P0.05).The RR value decreased after 3 h,and lower than pre treatment(P0.05),then increased slightly.The Raw increased significantly after 1h(P0.05),then decreased slowly.Otherwise,other indexes,including pH value,C,HR,MAP and CVP didn't showed obvious change before and after treatment.Conclusion It demonstrated that oxygenation was improved obviously with mechanical ventilation in prone position.