Clinical evaluation of early low-dosage peritoneal dialysis in elder chronic renal failure patients

Objective: To investigate the clinical value of early low-dosage peritoneal dialysis in elder chronic renal failure patients. Methods:16 elder patients aged from 64 to 74 with chronic renal failure were included in this study.Glomerular filtration rate(GFR),expressed by the average of urea and creatinine clearence rates,of all the patients changed from 10.7 to 11.7 ml/min.The dialysis dose was adjusted according to the guide-line of peritoneal dialysis adequacy demanding Tkt/v2.0,TCcr 60 L/W. Most of the patients accepted the peritoneal dialysate containing 1.5% glucose,while some patients accepted the peritoneal dialysate containing 2.5% glucose interruptedly to get more fluid removal. The clinical data of the 16 cases were collected before the renal replacement treatment and 6,12 months after the treatment. Results: The dialysis dose(PV/S) of all the patitents was 3.21～3.36 L/m 2.There was no significant difference in residual renal function during the one-year period of treatment, P0.05.Food appetite and physical status were improved in most of the patients after the treatment of peritoneal dialysis. The serum albumin level after peritoneal dialysis was significant higher as compared with the pre-dialysis state,(37.1±4.4)g/L vs (33.7±5.4) g/L,P0.05. Subjective global assessment was also improved significantly, P0.05. Although only five patients received recombinant human erythropoietin treatment,the hemoglobin levels one year after the dialysis were significant higher than those before the dialysis, (99.1±7.9)g/L vs (71.0±6.8)g/L, P0.05. And after the dialysis,the rates of hospitalization were significantly reduced,P0.05. Conclusion: Early low-dosage peritoneal dialysis can improve the nutritional status,hemoglobin and quality of life in elder chronic renal failure patients and reduce the hospitalization rates.