Comparison of effect of concurrent chemo-radiotherapy and sequential chemo-radiotherapy in the treatment of patients non-small cell lung cancer at stage III

Objective To explore the effect and security of concurrent and sequential chemo-radiotherapy in the treatment of patients with non-small cell lung cancer at stage Ⅲ.Methods.The clinical data of 86 patients with non-small cell lung cancer at stage Ⅲ from February 2006 to February 2009 were retrospectively analyzed,which included 46 cases undergoing concurrent chemo-radiotherapy and 40 cases receiving sequential chemo-radiotherapy treatment.Short term curative effect,median survival time and side effects were compared between two groups.Results The effective rates of treatment were 69.6% and 50.0% respectively in the concurrent chemo-radiotherapy group and in the sequential chemo-radiotherapy group with significant difference(P0.05).The median survival time in the concurrent chemo-radiotherapy group was superior to the sequential chemo-radiotherapy group(17.9 months vs 12.3 months,P0.05).The main adverse reactions were myelosuppression,radiation esophagitis,radiation pneumonitis and gastrointestinal reaction in the two groups.The incidence of Ⅲ~Ⅳ grade side effects in the concurrent chemo-radiotherapy group were higher than that in the sequential chemo-radiotherapy group with no significant difference(P0.05).Conclusion While compared with sequential chemo-radiotherapy,concurrent chemo-radiotherapy can greatly improve short term curative effects and survival time for patients with non-small cell lung cancer at stage Ⅲ.