Expression of cytokine in CD69 cell and CD69 on lymphocyte from patients with systemic lupus erythematosus

Objective:To investigate the expression of CD69+ on lymphocyte and cytokine in active lymphocyte (CD69+) from patients with systemic lupus erythematosus( SUE) . So try to understand the lymphocyte activation, expression of cytokine in active lymphocyte and the pathogenesis of SLE.Methods: Expression of CD69+ on lymphocyte and intracellular cytokine(IL-2,TNFα) in active lymphoycte(CD69+) were investigated in 26 SLE and 15 healthy volunteers by using flow cytometric analysis and immunofluorescence staining method. Results:Expression of CD69+ on lymphocytes from active and inactive SLE patients were significantly higher than that of healthy controls( P 0.05) . Expression percent of CD69+ on lymphocyte from patients with SLE were significantly correlated with SLEDAI(P0.05) .Active SLE patients had statistically significantly increased CD69+ cell producing IL-2,TNFα than healthy controK P 0.05). Conclusion:SLE patients had activation phenomenon of lymphocyte in body, this thing correlated with the pathogenesis of SLE. Moreover, expression of JL-2, TNFα in active lymphocyte were increased.