Comparision of intensity-modulated rdiation therapy and conventional radiotherapy for advanced cervical cancer without lymph node metastasis

Objective To discuss the clinical significance of intensity modulated radiation therapy(IMRT)in advanced cervical cancer without lymph node metastasis.Methods Thirty-five patients of advanced cervical cancer without lymph node metastasis were observed in our study.Fifteen Patients were treated by IMRT,and the others were treated by conventional radiotherapy(CRT).We compared short-term efficacy and complications between two groups.Results The tumor regression rates were 86.7% for IMRT group and 75.0% for CRT group(P0.05).The 1-year and 2-year survival rates were respectively 86.7% and 60.0% in IMRT group,which were no significant difference compared with those in CRT group(80.0% and 50.0%)(P0.05).The incidence rates of acute gastrointestinal tract and urinary system radiation reaction in IMRT group were significantly lower than those in the CRT group(P0.05).Bone marrow suppression was no significant difference between two groups(P0.05).Ⅲ-Ⅳ grade gastrointestinal and urinary tract serious reaction did not appear in both groups.The incidences of long-term radiation proctitis,cystitis,intestinal obstruction,pelvic fibrosis,were 20.0%,6.7%,6.7%,6.7% in IMRT group,which were significantly lower than those in CRT group(P0.05).The incidence of vaginal adhesions was no significant difference between IMRT group and CRT group(P0.05).Conclusion Compared with CRT in advanced cervical cancer without lymph node metastasis,IMRT did not improve local tumor control rate and the recent survival rate,but significantly reduced the response to acute and chronic radiation The clinical significance of IMRT in advanced cervical cancer without lymph node metastasis should be promoted.