CD44V6 and C-erbB-2 Expression in Non-Small Cell Lung Carcinomas and Its Significance

Objective:To investigate the relationship between CD44V6 and C-erbB-2 expression and clinicpathologic characteristics in non-small cell lung carcinomas(NSCLC).Methods:CD44V6 and C-erbB-2 protein was detected by S-P immunohistochemical method in 132 cases of NSCLC, 66 cases of metastatic lymph nodes, 95 cases of paracancer lung tissue and 20 cases of normal lung tissue.Results:CD44V6 positive expression of NSCLC was 48.48%, significantly higher than that of paracancer lung tissue(16.84%) and normal lung tissue(20.00%). CD44V6 positive expression was significant correlation with lymph nodes status, TNM stage, tumor size and histological type, but was not significant correlation with the patients sex, age, and histological grade. CD44V6 positive expression in NSCLC with lymph node metastasis, TNM stage Ⅲ,tumor 3cm diameter and squamous cell carcinomas was significantly higher than that without lymph node metastasis, TNM stage Ⅰ,Ⅱ, tumor ≤3cm diameter and adenocarcinomas. CD44V6 positive expression of metastatic lymph nodes was significantly higher than that of primary lung carcinomas. C-erbB-2 positive expression of NSCLC was 61.36%, significantly higher than that of paracancer lung tissue (18.95%) and normal lung tissue (10.00%).C-erbB-2 positive expression was not significant correlation with clinicopathologic characteristics.Conclusion:CD44V6 positive expression indicated that NSCLC has stronger invasion and metastasis potential. CD44V6 is a useful marker of predicting the metastatic potential and the prognosis of NSCLC. C-erbB-2 is not an useful marker for predicting the prognosis of NSCLC.