Effect of sevoflurane on pro-inflammatory cytokines in the perioperative period of gastric cancer

Objective: To study the effect of sevoflurane on pro-inflammatory cytokines in gastric cancer surgery. Methods: Thirty patients of gastric cancer were divided into two groups randomly: Control group (n=15)and Sevoflurane group (n=15). There was no statistically significant difference between two groups in general state of health. In Sevoflurane group, from the beginning of the operation to the end, patiens were given continuously 1% sevoflurane inhalation. Plasma levels of tNF-a、 IL-6、IL-8 were measured at the following moments, immediately after induction of anesthesia(T1),immediately after intra-abdominal exploration (T2), immediately after surgery (T3), 2 h and 4 h after surgery(T4 and T5). Results: Plasma levels of TNF-a, IL-6, IL-8 were normaland there was no statistically significant difference between two groups in the moment of T1. Compared with T1, the levels increased significantly at T2～T5 in both groups (P0.05).The levels of TNF-a, IL-6, IL-8 in sevoflurane group were significantly lower than those in the control group in the moments of T2, T3, T3, T4, T(5P0. 05). Conclusion: Sevoflurane can effectively inhibit the inflammation response in gastric cancer surgery.