Chemotherapy and late course three dimensional conformal radiotherapy in the treatment of stage III non-small cell lung cancer

Objective:To evaluate the efficacy and complications of chemotherapy and late course three-dimensional conformal.radiotherapy (3DCRT)for stage III non-small cell lung cancer(NSCLC).Methods: The 64 patients with stage III NSCLC were randomized into two groups : thirty-two patients received chemotherapy and late course 3DCRT(3DCRT group),32 patients received chemotherapy and conventional fraction radiation (control group) ,all patients were given with 6/15 MV X-ray total tumor dose was 40Gy , followed by 3DCRT,2.5Gy～3.0Gy per fraction ,1fraction qd, total dose of 68Gy～70Gy, and followed by conventional fraction radiation, total dose of 64～66Gy.Chemotherapy regimen was EP(VP-16 and DDP).Results: The 1 and 2-year survival rates in 3DCRT group and control group were 87.5%,56.3% and 65.6%,34.4% ( P0.05 ) ; local control rates were 90.6%,81.3% and 65.6%,53.1%(P0.05).Conclusion: Chemotherapy and late course 3DCRT can improve the survival rate in stage III NSCLC without severe toxicities.