Application of cardiac troponin I, myoglobin, creatine kinase MB to the diagnosis of myocardial injury during open heart surgery under cardiopulmonary bypass

【Objective】To evaluate the clinical value of cardial troponin Ⅰ (cTnI), myoglobin(Myo) and creatine kinase MB (CK-MB) in the diagnosis of myocardial injury during open heart surgery under cardiopulmonary bypass (CPB). 【Methods】With electrochemiluminescence (ECL) method, the serum levels of cTnI, Myo and CK-MB at 8 time points in 30 open heart surgery patients were measured respectively. 【Results】The serum levels of cTnI , Myo and CK-MB began to increase from the onset of CPB(T2) and were significantly higher than preoperative value(T1) (P 0.01), then increased gradually, cTnI and Myo reached the peak concentrations after CPB 30 minutes (T4) and CK-MB reached the peak after CPB 2 huors (T5), the levels then decreased gradually, but after CPB 24 hours (T8) their levels were still higher than preoperative value (T1) (P 0.01). 【Conclusion】The application of cTnI in the diagnosis of my-ocardial injury during open heart surgery under cardiopulmonary bypass is more valuable than CK-MB and Myo.