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2006•Chinese Journal of New Drugs and Clinical RemediesRequires access

Intestinal peptide transporter and application for improving oral absorption

HE Zhong-gui

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Abstract

Peptide transporters that expressed in the intestinal brush border membrane (PEPT1) and peptide transporter that expressed in the basolateral membrane were the two subtypes of peptide transporter (PEPT) . They played an essential role in absorption of oligopeptides and peptidomimetic drugs. PEPT1 was a key target for approach of prodrug. Not well absorbed drugs could be appropriately designed in the form of di-/ tripeptide analogues to be well absorbed across the intestinal brush border membrane via PEPT1 and thus increase the valuable oral bioavailability.

About this research paper

What this paper is about

Peptide transporters that expressed in the intestinal brush border membrane (PEPT1) and peptide transporter that expressed in the basolateral membrane were the two subtypes of peptide transporter (PEPT) . They played an essential role in absorption of oligopeptides and peptidomimetic drugs. PEPT1 was a key target for approach of prodrug. Not well absorbed drugs could be appropriately designed in the form of di-/ tripeptide analogues to be well absorbed across the intestinal brush border membrane via PEPT1 and thus increase the valuable oral bioavailability.

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Available abstract

Peptide transporters that expressed in the intestinal brush border membrane (PEPT1) and peptide transporter that expressed in the basolateral membrane were the two subtypes of peptide transporter (PEPT) . They played an essential role in absorption of oligopeptides and peptidomimetic drugs. PEPT1 was a key target for approach of prodrug. Not well absorbed drugs could be appropriately designed in the form of di-/ tripeptide analogues to be well absorbed across the intestinal brush border membrane via PEPT1 and thus increase the valuable oral bioavailability.

Key concepts: Tripeptide, Peptide, Transporter, Prodrug, Brush border, Oligopeptide, Peptidomimetic, Bioavailability

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