Quantitative analysis of radiopharmaceutical imaging of salivary gland in Sjgren's syndrome

Objective To study the diagnostic value of quantitative analysis of radiopharmaceutical imaging of salivary gland on Sjgren's syndrome. Methods After intravenous injection of 370 MBq 99 Tc m sodium pertechnetate, anterior dynamic salivary gland images were obtained for 50 min. Forty minutes after injection, 0.5 g Vit C were administered intraorally as a stimulus. A time-activity cure of each salivary gland was drawn and functional parameters were calculated with dynamic salivary gland images. Results The uptake rate (UR) of the parotid and submandibular glands in patients with Sjgren's syndrome was 2.8±1.2 and 1.6±0.7, that of normal controls was 5.1±1.4 and 3.4±0.6, respectively (P 0.01 ). The T_ min of the parotid (3.9±2.5) and submandibular glands (5.1±2.3) significantly increased in Sjgren's syndrome compared with normal controls (1.8±1.1 and 2.4±1.4,P0.01). The T_ max of the parotid and submandibular glands in patients with Sjgren's syndrome was not different compared with normal controls. Conclusion Determining UR and T_ min are very sensitive mark to estimate function of the parotid and submandibular glands in patients with Sjgren's syndrome; There is not clinical value on analysing T_ max of salivary gland in patients with Sjgren's syndrome.