Efficacy of intravitreal gas injection for retinal detachment resulting from macular hole in myopic eyes

Objective To evaluate the efficacy of intravitreal gas injection in treating retinal detachment due to macular hole in high myopia,compared with pars plana vitrectomy(PPV) with intraocular gas tamponade.Design Prospective,randomized controlled case series.Participants 24 eyes of 24 patients with retinal detachment owing to myopic macular hole in Beijing TonRen Hospital.Methods All patients were randomly assigned to undergo intravitreal perfluoropropane(C3F8) gas injection(group A) or vitrectomy with intraocular C3F8 gas tamponade(group B).Complete ocular examination included best-corrected visual acuity,intraocular pressure,slit-lamp biomicroscopy,color fundus photography,ultrasound examination,and optical coherence tomography at baseline and every 3 months after the surgery.The follow-up time was 27.3±12.8 months after operation.Main Outcome Measures Retinal reattachmentrates,the postoperative best-corrected visual acuity and the costs during the treatment.Results At the last follow-up after surgery,the retinal reattachment rates in group A was 28.6%(4 cases) and 20%(2 cases)(P=1.00) and the visual improvement(≥2 lines) rate in group A was 28.6%(4 cases) and 20%(2 cases)(P=1.00).But the costs between two groups was significantly different(P=0.000).Conclusion Intravitreal C3F8 gas injection alone was a safe,effective and low cost way in treating retinal detachment owing to macular hole in high myopia.