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2010•Journal of Heze Medical CollegeRequires access

The effect of hemin on the CA1 neurons in the hippocampus of rats with global cerebral ischemia

Xinqing Guo

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Abstract

Objective The study was undertaken to investigate the effect of hemin on the CA1 neurons in the hippocampus of rats with global cerebral ischemia.Methods 24 male Wistar rats were randomly divided into 3 groups.Globalbrain ischemia was produced by the fourvessels occlusion method.The death of neurons was examined with neuropathological evaluation under thionin staining.Results There was obvious DND in the CA1 area of the global brain ischemia group.Compared with the global brain ischemia group,Hemin therapy group was not any better(P0.05).Conclusion The results suggested that therapeutic administration of Hemin in any doses used had no protective effect on hippocampus of rats with global cerebral ischemia.

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What this paper is about

Objective The study was undertaken to investigate the effect of hemin on the CA1 neurons in the hippocampus of rats with global cerebral ischemia.Methods 24 male Wistar rats were randomly divided into 3 groups.Globalbrain ischemia was produced by the fourvessels occlusion method.The death of neurons was examined with neuropathological evaluation under thionin staining.Results There was obvious DND in the CA1 area of the global brain ischemia group.Compared with the global brain ischemia group,Hemin therapy group was not any better(P0.05).Conclusion The results suggested that therapeutic administration of Hemin in any doses used had no protective effect on hippocampus of rats with global cerebral ischemia.

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Available abstract

Objective The study was undertaken to investigate the effect of hemin on the CA1 neurons in the hippocampus of rats with global cerebral ischemia.Methods 24 male Wistar rats were randomly divided into 3 groups.Globalbrain ischemia was produced by the fourvessels occlusion method.The death of neurons was examined with neuropathological evaluation under thionin staining.Results There was obvious DND in the CA1 area of the global brain ischemia group.Compared with the global brain ischemia group,Hemin therapy group was not any better(P0.05).Conclusion The results suggested that therapeutic administration of Hemin in any doses used had no protective effect on hippocampus of rats with global cerebral ischemia.

Key concepts: Hemin, Medicine, Hippocampus, Ischemia, Brain ischemia, Occlusion, Anesthesia, Internal medicine

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