Efficacy observation of different doses of bortezomib in the treatment of multiple myeloma

Objective To observe the efficacy and adverse reaction of different doses of bortezomib in the treatment of multiple myeloma.Methods 43 cases of myeloma patients were treated with bortezomib which was the main medicine in chemotherapy regimen for treatment(bortezomib 1.0 ~ 1.3mg·m-1·d-1,the 1st,4th,8th,11th day,doxorubicin 20mg/d,in 1 ~ 4 days;Combined with or without thalidomide 100mg,taking before going to bed every night;21d for 1 courses).According to bortezomib dose,they were divided into high dose group(1.3mg·m-1·d-1,20 cases) and low dose group(1.0mg·m-1 ·d-1,21 cases).All the Patients were treated for 1 ~ 6 courses.Results After treatment,the total effect rate of the high dose group was 85.0%,which was higher than 71.4% of the low dose group,and the difference was statistically significant(P 0.05).14 cases of patients occurred adverse reactions in high dose group,10 cases of patients occurred adverse reactions in low dose group,there was no significant difference in 2 groups(P 0.05).Conclusion The high dose bortezomib has greater clinical effect in the treatment of multiple myeloma.Although some adverse reaction,but the patients were well tolerated.