Relationship between heart rate variability and type 2 diabetes mellitus: a report of 117 cases

Objective The past studies have demonstrated that heart rate variability( HRV) was significantly decreased in type 2 diabetes mellitus( T2DM) patients. The current study aimed to investigate the relationship between T2DM and HRV by using 24 hour dynamic echocardiogram. Methods 42 cases of T2DM confirmed by oral glucose tolerant test( OGTT) were enrolled in this study as observation group,while 75 subjects without abnormal glucose metabolism were recruited as control group. 24-hour Holter electrocardiography was performed in all subjects. SDNN,RMSSD,pNN50,SDNN index and SDANN were analyzed and compared. Results SDNN,RMSSD,pNN50 and SDNN index were( 121. 61 ± 34. 49) ms,( 54. 07 ± 31. 91) ms,( 10. 13 ± 10. 00) % and( 41. 92 ± 20. 47) ms,respectively,in the control group,and( 103. 93 ±29. 98) ms,( 44. 22 ±19. 62) ms,( 5. 85 ±5. 69) % and( 32. 04 ±11. 2) ms,respectively,in the observation group,the difference in the above HRV indexes were significant between the two groups( P 0. 05). SDANN was( 72. 90 ±56. 81) ms in the control group and( 64. 10 ± 45. 11) ms in the observation group,there was no significant difference between the two groups( P 0. 05). Conclusion The reduced HRV indexes( except SDANN) in T2DM patients may be possibly associated with the impaired vagus nerve.