Effect of clopidogrel on platelet function in patients with unstable angina pectoris

AIM:To investigate the effect of clopidogrel on platelet activation in patients with unstable angina pectoris(UAP), and to discuss its clinical value.METHODS:85 UAP patients were randomly divided into three groups: clopidogrel loading dose group( n =30),clopidogrel routine dose group( n =30) and ticlopidine group( n =25). All the patients were given aspirin 300 mg/d as the base treatment, then the colpidogrel loading group patients were given polivex bolus 300 mg;the clopidogrel routine dose group patients were given polivex 75 mg/d on 3 successive days and the ticlopidine group patients were given ticlid 250 mg/d on 3 successive days. 2 hours after the first drug intake of clopidogrel loading dose group, and 3 days after drug intake of clopidogrel routine dose group and ticlopidine group. Venous blood was sampled for the determination of markers of plasma GMP-140 and max platelet aggregation rate(MPAR) induced by ADP pre-treatment. RESULTS:At post-treatment plasma GMP-140 antigen and MPAR of all the three groups were lower than pre-treatment( P 0.01),but there was no significant difference between the three groups( P 0.05). CONCLUSION: Clopidogrel takes effect quickly. Loading dose 300 mg can inhibit platelet activation in 2 hours,and achieve the similar effect gained by 3 successive days' administration of routine dose of clopidogrel or ticlopidine.