2009•Linchuang gandanbing zazhiRequires access
Protection of glutamine on intestinal barrier function in ethanol-induced liver injury in rats BAI
Peng Yan
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Abstract
Objective To investigate the changes of intestinal barrier function and protection of glutamine on chronic ethanol-induced liver injury in rats. Methods 36 SD rats were divided randomly into group A (normal control),group B (model) and group C (glutamine-treated) and the changes in liver biochemistry, intestinal mucosal permeability,bacterial translocation and intestinal mucosa pathohistology were detected,respectively. Results The serum AST(256.6±50.8 U/L vs. 175.2±16.2 U/L,P0.05) and ALT levels(86.5±5.4 U/L vs. 53.7±13.2U/L,P0.05),the intestinal mucosal permeability(62.5% vs. 0.0%,P0.05),and the bacterial translocation rate of intestinal tract(235.1±26.4 ml·min-1·cm2 vs. 30.1±33.6 ml·min-1·cm2,P0.05) increased obviously,and the pathological injury of intestinal mucosa (3.8±0.9 vs 0.4±0.5,P0.05) aggravated in group B as compared to in group A;while all the parameters in group C were alleviated as compared to in group B. Conclusion In experimental ethanol-induced liver injury in rats,glutamine has a protective role in liver and intestinal barrier injuries.