Effect of Perinatal Asphyxia on Kidney Function of Full-Term Newborns

Objective To investigate the effect of perinatal asphyxia on kidney function of full-term newborns.Methods Two hundred and thirty-three cases of full-term newborns with perinatal asphyxia(159 cases were male,and 47 cases were female;gestational weeks was 37-42+5 weeks;average body weight was 3 296 g),were divided into 3 groups:severe asphyxia group(37 cases),mild asphyxia group(100 cases),antepartum asphyxia group(96 cases),according to their Apgar scores and amniotic fluid conditions.One hundred healthy newborns were selected as healthy control group.All their serum creatinine(Scr) was measured by using sarcosine oxidase method and creatinine clea-rance(Ccr) was estimated by adopting Swatch formula.Results There were significant differences of Scr and Ccr between perinatal asphyxia group and healthy control group.Among perinatal asphyxia groups,there was only a significant difference of Ccr between severe asphyxia group and antepartum asphyxia group,and there was no statistic difference of Ccr and Scrc between severe asphyxia group,mild asphyxia group,and antepartum asphyxia group.Their Scr of 144 cases within 233 newborn infants with perinatal asphyxia exceed 50% compared with that in healthy control group,conforming to acute kidney injury,including 27 cases of severe asphyxia group,64 cases of mild asphyxia group,and 53 cases in antepartum asphyxia group.One hundred and twenty-nine cases improved,improvement rate was 89.58%(129/144 cases),including 85.19% in severe asphyxia group(23/27 cases),89.06% in mild asphyxia group(57/64 cases),92.45% in antepartum asphyxia group(49/53 cases).One case died,14 cases gave up treatment due to serious pathogenetic condition,unfavourable prognosis rate was 10.42%.Conclusions Once there was perinatal asphyxia,part of full-term newborns,whose glomerular filtration rate was decreased,had acute abnormal renal function in different degrees,even if it was not consistent with the diagnosis of acute renal insufficiency due to anoxia and ischemia.Acute renal injury should be considered and diagnosis should be done as early as possible.Improvement of hypoxia status can prevent the deterioration of renal function and can decrease mortality rate.