The Effect of Rosiglitazone and Samvastatin Preventing Artherosclerosis in Rabbit

Objective To study the effect of rosiglitazone on atherosclerosis and potential mechalism in rabbits.Methods Fourty healthy Japanese big-ear rabbits were randomly divided into five groups with 8 rabbits in each group:normal control group,model group,rosiglitazone group,simvastatin group,rosiglitazone and simvastatin group.Group A were fed with common forage for 10 weeks;group B were fed with fat forage(common forage contained 1% cholesterol and 8% lard);group C were fed with fat forage and rosglitazone 0.5/kg/day;group D were fed with fat forage and samvastatin 2.5/kg/day;group E were fed with fat forage and rosglitazone 0.5/kg/day and samvastatin 2.5/kg/day.At the end of the experiment,the rabbit blood samples were collected for biochemistryl analysis and aorte were prepared for morphologic analysis.Results The level of CRP in group C,group D,group E were significantly greater than that of model group.The level of ADMA were lower in group A,group C and group E than in group B and group D.Group C,group D and group E reduced the extend of atherosclerosis of longitudinal section.Conclusion Rosiglitazone and Samvastatin can prevent the development of atherosclerosis through inhibiting the inflammatory reaction and the effect of them were synergetic.