Synthesis of 4-amino benzoic acid

With aniline as raw material,through acylation and iodoform reactions,the target compound 4-amino benzoic acid was synthesized and characterized by IR,1H NMR and 13C NMR.In the acylation reaction,the influences of dosage of catalyst AlCl3,reaction temperature and reaction time on the yield of intermediate 4-amino acetophenone were investi-gated.In the iodoform reaction,the influences of reaction temperature,reaction time and dropping speed of 4-amino ace-tophenone on the yield of 4-amino benzoic acid were investigated.Under the optimal conditions,the yield of 4-amino ben-zoic acid was 94.0% with purity of 99.7%.