[Detection of panel-reactive antibody before and after renal transplantation: analysis of 641 cases].

OBJECTIVE: To explore the significance of the panel-reactive antibody (PRA) detection in renal transplantation. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to measure the PRA levels in 641 patients with renal transplantation, of whom 570 were examined preoperatively while 71 postoperatively. RESULTS: Of the 570 cases examined preoperatively for PRA levels, 490 cases were negative of PRA in which acute rejection occurred in 35 cases (7.14%) after the transplantation, while in the 68 cases with slightly positive PRA as detected preoperatively, acute rejection occurred in 36 cases (52.9%). Among the 12 cases with positive PRA assay both before and after the operation, acute rejection took place in 10 cases (83.3%). As for the 71 patients receiving postoperative PRA detection, 59 were PRA-negative, among whom acute rejection occurred in only 3 cases (5.08%), while 7 (58.3%) out of the 12 PRA-positive experienced episodes of acute rejection. CONCLUSION: PRA-positive recipients of the renal transplantation have higher risks of acute rejection of the graft, and PRA detection both before and after the operation may be of great importance.