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Supercritical-CO_2 fluid extraction of taxol from branches and needles of Taxus Yunnanensis

Liu Li

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Abstract

AIM: To study the supercritical-CO_2 fluid extraction of taxol from branches and needles of Taxus Yunnanensis. METHODS: Pure CO_2 was used to remove lipid in branches and needles of Taxus Yunnanensis and then methanol was used as modifier to extract taxol.A HPLC method was developed for the determination of taxol content in extracts. RESULTS: Taxol could be extracted from branches and needles of Taxus Yunnanensis which was grinded to powder of diameter about 0.6-0.8 mm at 34 MPa and 40 ℃ when methanol was used as modifier. CONCLUSION: Comparing with traditional solvent extraction method,supercritical-CO_2 fluid extraction can improve extraction yield of taxol and protect natural environment because of its less wasted solvent and short time.

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What this paper is about

AIM: To study the supercritical-CO_2 fluid extraction of taxol from branches and needles of Taxus Yunnanensis. METHODS: Pure CO_2 was used to remove lipid in branches and needles of Taxus Yunnanensis and then methanol was used as modifier to extract taxol.A HPLC method was developed for the determination of taxol content in extracts. RESULTS: Taxol could be extracted from branches and needles of Taxus Yunnanensis which was grinded to powder of diameter about 0.6-0.8 mm at 34 MPa and 40 ℃ when methanol was used as modifier. CONCLUSION: Comparing with traditional solvent extraction method,supercritical-CO_2 fluid extraction can improve extraction yield of taxol and protect natural environment because of its less wasted solvent and short time.

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Available abstract

AIM: To study the supercritical-CO_2 fluid extraction of taxol from branches and needles of Taxus Yunnanensis. METHODS: Pure CO_2 was used to remove lipid in branches and needles of Taxus Yunnanensis and then methanol was used as modifier to extract taxol.A HPLC method was developed for the determination of taxol content in extracts. RESULTS: Taxol could be extracted from branches and needles of Taxus Yunnanensis which was grinded to powder of diameter about 0.6-0.8 mm at 34 MPa and 40 ℃ when methanol was used as modifier. CONCLUSION: Comparing with traditional solvent extraction method,supercritical-CO_2 fluid extraction can improve extraction yield of taxol and protect natural environment because of its less wasted solvent and short time.

Key concepts: Taxus, Extraction (chemistry), Supercritical fluid, Supercritical fluid extraction, Methanol, Chromatography, Yield (engineering), Chemistry

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Supercritical-CO_2 fluid extraction of taxol from branches and needles of Taxus Yunnanensis — Research Paper | ScholarLens